Oxazoline heterocycles are active components in a broad range of pharmaceutical products. A challenging task remains in finding a reliable and efficient method to synthesize these compounds through inexpensive and environmentally benign reagents. In this study, we are able to efficiently produce oxazolines through coupling of <i>N</i>,<i>N</i>-dichloroamides and alkenes. Advantage of our method is in its use of trichloroisocyanuric acid (TCCA), an inexpensive bleaching agent.

Efficient routes to oxazolines through activation of aromatic amides

2019 Fall National Meeting

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