We investigate nonspecific interactions between model membranes and nanomaterials. Nanomaterials have found broad applications in fields, including for environmental sensing, drug delivery, and cell imaging.  The ecotoxicology and environmental impact of nanomaterials depend on interactions with the membrane of living cells. In order to foster applications on the cellular biochemical level, it is essential to commence systematic investigation of nanomaterials and their membrane interactions. In light of the complexity of cell membranes, a simplified model system, so called Droplet Interface Bilayer (DIB), is used. A DIB is a model lipid bilayer existing between two aqueous droplets, submerged in an oil phase, each of which is stabilized by a lipid monolayer. Our present studies build on this platform to use the water permeability coefficient as an assay from which to deduce the structural modulation of a lipid bilayer induced by interaction with nanomaterials. Variations in the compositional library of the lipid bilayer permit us to determine whether these nanomaterials preferentially interact with specific lipids or lipid mixtures. This study will contribute to an increased understanding of how subtle compositional variations in the environment surrounding the liquid-liquid interface can have significant relevance for biological membranes and their physicochemical properties

Interactions of nanomaterials with model lipid bilayer

2019 Fall National Meeting

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