There has been growing biological applications of dendrimer-based nanomaterials in recent years, such as the use as drug or gener delivery vehicles. However, one of the major challenges is related to the dendrimer uptake into the cell and resulting the disruption of lipid bilayers and the cytotoxicity. Therefore, it is important to understand how these dendrimer-based nanomaterials interact with biological membranes for the successful development of pharmaceutical agent and wider biomedical application based on these materials. Polyamidoamine (PAMAM) dendrimers are highly branched synthetic macromolecules with various level of branching described by the generation Gn. In this study, we investigated the water permeability of the simple models of biological membrane, lipid bilayers, made by Droplet Interface Bilayer method. In addition, we also investigated the thermal properties of lipid membranes using liposome as model system. As cell membranes, we used both saturated and unsaturated lipid molecules to form a lipid bilayer and their interactions with various generations of PAMAM dendrimers. Our findings will provide an insight into the nature of interaction between dendrimers with a lipid interface.

Interactions of PAMAM dendrimers with lipid bilayers

2019 Fall National Meeting

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