Nucleosides are an important class of compounds to address serious unmet medical needs. These molecules are also extremely difficult to synthesize without excessive use of protecting groups, especially compounds containing unnatural sugar and base moieties. In addition, these compounds contain numerous stereocenters that are often difficult to set with high selectivity. As process chemists, we strive to find the most direct method to convert commodity chemicals into the target API. In this presentation, a variety of solutions will be reviewed to achieve aspirational syntheses of diverse nucleoside targets, ranging from organo- to biocatalysis.

Innovation for the synthesis of diverse nucleosides

ACS Spring Meeting 2021

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.