En route for highly functional biomaterials and nanodevices, amphiphilic block copolymer structures are gaining in complexity and precision in their macromolecular structure. In addition to their intrinsic self-assembly properties, they may include stimuli-responsiveness possibly in addition to relevant biological functions. By combining the self-assembly properties of block copolymers together with the richness of function-bearing peptides, polypeptide and proteins, we aim at creating functional biomaterials. We were interested in designing copolymers able to self-assemble into well-defined micelles and vesicles that can advantageously be loaded with drugs and present a surface with multivalent presentation of bioactive building blocks that were shown to target specific cell receptors. We will especially focus on how the conformation and responsiveness of polypeptide-based materials can allow deep control in self-assembly processes.

Self-assembly of biomimetic polypeptide and protein based copolymers: From conformational control to functional biomaterials

ACS Spring Meeting 2021

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