The goal of the SWEATSENSER Dx platform is to demonstrate clinically relevant wearable electrochemical biosensor system that continuously tracks WELLNESS-ILLNESS-WELLNESS states in the wearer. The premise of this technology is in establishing that physiological changes in a person precedes the symptoms for a variety of ILLNESSES, and that these changes in conjunction with vitals are traceable to changing levels of multiple pro- and anti-inflammatory cytokines released and presented in passively expressed Sweat in response to inflammation or infection events.<br/>A “cytokine storm” in a flu infection, is often associated with a surge of activated immune cells into the lungs. The resulting lung inflammation and fluid buildup can lead to respiratory distress and can be contaminated by a secondary bacterial pneumonia -- often enhancing the mortality in patients. The cytokine storm is thought to occur in at least several types of infections and autoimmune conditions, but it appears to be particularly relevant in outbreaks of new flu variants and more recently in Covid-19.<br/>SWEATSENSER Dx is a non-invasive, real-time sensing system that has demonstrated potential for rapidly assessing and monitoring temporal dynamics of cytokines from humans and has the capability of monitoring the cytokine storm, which is a current technological gap.  The ability to monitor a panel of cytokines in a non-invasive, temporally dynamic manner from passively expressed eccrine sweat that our SWEATSENSER Dx wearable platform technology provides is therefore has the potential as an enabling technology for proactively assessing health threats in a non-invasive manner while providing actionable data in an on-demand manner. Passively expressed Eccrine Sweat contains a plethora of health information including inflammatory cytokines. Our Wearable Point-of-Need SWEATSENSER Dx platform based on electrochemical biosensing system offering real-time, continuous reporting from passively expressed eccrine sweat (1-5 microliters) with no external stimulation, can rapidly detect (≤ 3 minutes), and continuously track multiple Cytokine biomarker levels from as low as 1 pg/mL to 10,000 pg/mL in a multiplexed manner in a person towards establishing the occurrence and progress of infection post-exposure and prior to the manifestation of symptoms to predicting an onset of a cytokine storm.

SWEATSENSER Dx an enabling technology for on demand profiling of cytokines on passively expressed eccrine sweat

ACS Spring Meeting 2021

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.