Hydrogen sulfide (H2S) has been identified as a third gasotransmitter, joining carbon monoxide and nitric oxide in this role. The currently identified biological functions of H2S are diverse, ranging from vasodilation to inflammation. Furthermore, this molecule has potential therapeutic applications for treating cardiovascular and neurodegenerative diseases. To more precisely assess the biological roles and to harness the therapeutic potential of H2S, compounds that slowly release this gasotransmitter at physiologically relevant concentrations are needed. In this presentation, we will discuss our efforts to apply transition metal-based compounds and materials for this application. Specifically, the description of systems that release H2S upon light activation, biological reduction, and hydrolysis will be presented. Furthermore, their potential therapeutic applications for minimizing the damaging effects of ischemic reperfusion injury will be demonstrated. This work highlights the potential of transition metal compounds for acting as novel H2S-delivery agents in biological systems.

Metal-based hydrogen sulfide-releasing agents for modulating cellular function

ACS Spring Meeting 2021

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