Amphiphilic molecules can spontaneously self-assemble into bilayer nanostructures at a liquid-liquid interface. This presentation features systems that mimic the structure and function of the cell membrane using self-assembly. These systems are constituted by the interface of a pair of contacting aqueous nanoliter droplets, each of which is covered with a lipid monolayer. These droplet interface bilayer (DIB) systems offer a powerful and controllable model for studying the fundamental physical chemistry of lipid bilayers. Using the DIB as a model biomembrane, we report results for rates of water transport across the bilayer interface that illuminate the exquisite interplay between structural factors of the bilayer and its chemical environment: water permeability parameters provide important insights into the aggregate structure of these soft membranes. The permeability of the DIB system allows us to probe the extent to which nanoparticles and small molecules may bind or perturb the lipid bilayer. This successful demonstration of soft surface engineering at the aqueous nanoliter droplet will provide important insights into the understanding of the lipid bilayer, an essential component of cellular membranes, and its interactions with surroundings.

Biomimetic self-assembly: The nanoliter aqueous microdroplet and insights into bilayer membrane structure

ACS Spring Meeting 2021

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.