The mitigation of infectious disease caused by bacteria and viruses is possible using β-lactam antibiotics. Unfortunately, bacteria's β-lactamases have drastically threatened the effectiveness of these antibiotics. β-lactamases are responsible for the resistance to most antibiotic drugs. It is a common practice to use β-lactam β-lactamase inhibitors to combat this resistance. However, in this study, we used 1,2,4-oxadiazolidinone as a non-β-lactam β-lactamases inhibitor against TEM-1 and P99 β-lactamases. Oxadiazolidinone is a five-membered ring structure similar to those in biologically active compounds like linezolid and avibactam. Treatment of nitrones with isocyanates produced oxadiazolidinones. The structural elucidation of these cycloadducts was determined using <sup>1</sup>H and <sup>13</sup>C NMR, GC-MS, and FTIR. Furthermore, Oxadiazolidinone's inhibition against TEM-1 and P99 serine β-lactamase was determined using nitrocefin as the substrate.

Synthesis and evaluation of 1,2,4 - oxadiazolidone: Search for potential non-β-lactam β-lactamase inhibitors

ACS Spring Meeting 2021

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