I will discuss the role water place in the mechanism of protofilament formation from peptides yeast prion peptide and Ab peptides as well how water molecules play an important role in amyloid polymorphism. I will show that spontaneous formation of two-ordered one-dimensional water wires in the pore between the two sheets of the Sup35 protofilaments results in long-lived structures, which are stabilized by a network of hydrogen bonds between the water molecules in the wires and the polar side chains. This behavior will be contrasted with Ab peptides in which expulsion of water between two sheets is rapid.

Role of water in protein aggregation and amyloid polymorphism

ACS Spring Meeting 2021

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.