In this work we report synthesis of in-vitro COVID-19 inhibition of an innovative 3-(Hydroxymethyl)-2-Phenyl-2,3 dihydroquinolin-4(1H)-one. The one-pot type reaction was sodium hydride mediated with intramolecular cyclization. The structures of the freshly synthesized compound was upheld by IR, 1H,13C NMR, EI-MS spectral studies, Chemo-informatics study showed that compound generally obeyed the Lipinski's rule, PASS, Swiss ADME, In-silico molecular docking study results demonstrated greater binding energy and affinity to the active pocket therefore, they may be considered as acceptable inhibitor and connection their structure and joint efforts with the receptor in the N3 binding site of the Coronavirus primary protease.

Design in-silico studies and synthesis of new 2-Phenyl-2,3 dihydroquinolin-4(1H)-one of interaction studies on COVID-19 main protease – inhibitor

ACS Spring Meeting 2021

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