The activation of unstrained, neutral C–N bonds as electrophiles is enabled through nickel catalysis. A nickel-catalyzed domino cross-electrophile coupling reaction of alkynyl substituted piperidines will be discussed. The scope of the reaction has been expanded to include substituents with both electron donating and electron withdrawing groups. The mechanism of this domino reaction has also been investigated utilizing a cross-over experiment.

Nickel-catalyzed domino cross-electrophile coupling reaction of alkynyl piperidines

ACS Spring Meeting 2021

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