While a great deal has been achieved in the field of colloidal nanoparticle chemistry over the past 40 years, the vast majority of work has been performed in low throughput, low yield batch reactions that result in milligrams to multiple grams of product at most. As industrial demand for colloidal nanoparticles increases, there is a growing need to scale up these batch chemistries in safe and sustainable ways. This talk highlights our work on using continuous flow reactors for the scalable manufacture of colloidal MoC<sub>1–<i>x</i></sub> nanoparticle catalysts. Flow reactors offer advantages over conventional batch reactors with respect to running continuously, offering superior reproducibility and reaction control, being automatable, and presenting environmental health and safety benefits by operating on demand. We will present recent results on using statistical design of experiments (DoE) methods to expeditiously maximize manufacturing throughput using a multivariate screening of the parameter space followed by response surface methodology to find the optimal response.

Route to manufacture colloidal nanoparticle catalysts: Continuous flow methods from a chemist’s perspective

ACS Spring Meeting 2021

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