Novel silica–KF reagent prepared by hydrolyzing tetraethyl orthosilicate in the presence of KF for fluorination of activated aromatic compounds has been reported. The reagent, as characterized by techniques such as SEM-EDX, XRD and IR spectroscopy, is shown to have potassium cations entrapped inside the silica matrix whereas fluoride anions remain on the surface. The reaction of activated chlorinated aromatic substrates with this silica–KF leads to the formation of Meisenheimer complex, either <i>in situ</i> or isolable, finally resulting in regioselective fluorinated aromatics.

Preparation and characterization of a novel silica–KF composite and facile fluorination of aromatic substrates

ACS Spring Meeting 2021

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