For the purpose of ensuring the bioavailability of bioactive ingredients, a nano-delivery system was developed using metal organic framework. Two kinds of zeolitic imidazolate framework-8 loading with curcumin (CCM@ZIF-8) was synthesized by high-temperature one-pot method and room-temperature two-steps method respectively. The characteristic of CCM@ZIF-8 particle was also demonstrated by the analysis of morphology and crystalline structure. From the results of FTIR and BET, CCM@ZIF-8 by high-temperature one-pot method (CCM@ZIF-8-HT) had encapsulated CCM molecular into the framework structure of ZIF-8, and those by room-temperature two-steps method (CCM@ZIF-8-RT) had a few curcumins embedded into the surface of ZIF-8. This difference lead CCM@ZIF-8-HT with higher curcumin encapsulation efficiency than CCM@ZIF-8-RT. An <i>in vitro</i> release study showed that 96.57±0.79% curcumin released from CCM@ZIF-8-HT during simulated gastric fluid transportation because ZIF-8 had no resistance to low pH environment. Compared to this, CCM@ZIF-8-RT could retained a large part of curcumin and transported to simulated small intense and colon, which related to the curcumin embedded into ZIF-8 and reduced the erosion from acidic medium. Furthermore, with room-temperature two-steps method, a ZIF-8 nanoparticle loading with BSA was synthesized. Similarly, this nanoparticle also exhibited controlled releasing profile for protein delivery. This study will make a development of MOF as carrier material in functional food.

Zeolitic imidazolate framework-8 applied in functional food for curcumin intestinal delivery

ACS Spring Meeting 2021

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