Most resin glycosides exhibited only moderate inhibition activity against cancer cell growth. However, ipomoeassin F is exceptionally cytotoxic. To accelerate ongoing chemical biology research on ipomoeassin F, research in our group is focused on the total synthesis of a novel simplified open-chain analogue <b>1 </b>from commercially available D-glucose and L-arabinose based on previous SAR studies. It is expected that biological assessment of the analogue <b>1 </b>would direct future design of ipomoeassin - derived chemical probes for studying biological pathways related to protein biogenesis.

Synthesis of open chain analogue of ipomoeassin F

ACS Spring Meeting 2021

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