In the U.S., lung cancer is by far the leading cause of cancer-related deaths among both men and women with more deaths caused by lung cancer than by breast, prostate, and colon cancer combined. Approximately 85% of lung cancers are within a group of histological subtypes collectively known as non-small cell lung cancer (NSCLC). Since pyrazoles and pyrazolones have shown great promise in recent years as pharmaceutical agents in medicinal chemistry, a series of pyrazolone compounds with different substitution patterns have been synthesized using microwave reaction conditions. An evaluation of the pyrazalones testing their <i>in vitro</i> antiproliferative activity against two NSCLC cell lines (A549 and NCIH522) showed that certain compounds exhibited potent antiproliferative activities and they might be promising anticancer drug candidates for further study. The details of cell cycle analysis and kinase inhibitor screening will be discussed in the presentation.

Synthesis and biological evaluation of 1,3-Diarylpyrazol-5-ones as potential anticancer agents

ACS Spring Meeting 2021

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