Controlled nanostructuring of electrode surfaces can be used enhance biomolecular capture rates and efficiencies. By immobilizing biomolecules on nanostructured surfaces, high-performance biomolecular detection systems can be developed to facilitate rapid biomarker analysis and the detection of infectious pathogens.  We have developed electrochemical assays that are able to detect nucleic acids, proteins and small molecules, with universally high sensitivity levels and have applied this approach in a variety of areas including noninvasive monitoring via Liquid Biopsy. This talk will highlight how electrodeposited metals can be used to create high-performance sensors that can be applied to a broad collection of clinically-relevant analytes, and will discuss how surface morphology, surface area and molecular diffusion can affect the detection limits obtained.  Recent progress linking these sensors with gene circuits and reagentless readout will be discussed.

Tuning biomolecular display on nanostructured surfaces for high-performance sensing

ACS Spring Meeting 2021

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.