Either hypoxia in acute ischemic stroke before thrombolysis or oxygen-boost after thrombolysis cause high level of free radical resulting in successive injuries to neurocytes. To treat ischemic stroke, it is needed to scavenge free radical combining sequentially regulating hypoxia and oxygen-boost microenvironment. Here, we report an engineered nanosponge (Mn<sub>3</sub>O<sub>4</sub>@nanoerythrocyte-T7, MNET) that could remodel the microenvironment of stroke by self-adapted oxygen regulating and free radical scavenging. With a long circulation time in blood due to stealth effect of erythrocyte, and preferential accumulation in infarct site by the assisting of T7 peptide， MNET exerts distinct therapeutic effect in two stages of ischemic stroke: i) before thrombolysis, rescue neurocyte via rapid free radical scavenging and timely oxygen supply; ii) after thrombolysis, suppress oxygen-boost via oxygen storage, as well as scavenge free radical to avoid reperfusion injury. MNET holds an attractive potential for ischemic stroke treatment via phased regulation of pathological microenvironment.

Bioinspired nanosponge for salvaging ischemic stroke via free radical scavenging and self-adapted oxygen regulating

ACS Spring Meeting 2021

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