Planar chiral macrocycles remain a significant synthetic challenge. The synthesis of atropisomerically pure macrocycles can be achieved using biocatalysis. Employing a commercially available immobilized lipase (CALB) and simple starting materials, 23 planar chiral macrocycles were prepared (11-88 % yield, 96-&gt;99 % <i>ee</i>). Importantly, planar chiral macrocycles having halogen or borylated substituents permit diversification to structures outside the boundaries of what may be tolerated by the enzyme.

Biocatalytic synthesis of planar chiral macrocycles

ACS Spring Meeting 2021

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.