Abstract: Application of ammonium formate for the conversion of variety of compounds containing mono or poly unsaturated functional groups selectively to their reduced derivative in the presence of metal catalyst have been successful in organic synthesis. Isopropyl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate also known as Fenofibrate contains a ketone group, which is chemically converted to methylene moiety in a single step by employing catalytic amount of Pd-C, ammonium formate in glacial acetic acid at 60 °C. Fenofibrate is shown to inhibit the enzyme activity of reaction catalyzed by Aldose Reductase which is a member of Aldo-Keto reductase family of proteins. Fibrates display clinical benefits when they are administered for the treatment of metabolic disorders, diabetic complications, hyperlipidemia and heart disease and were believed to act as agonist for the nuclear receptor previously. Herein we present the methodology properties of the methylene derivative of Fenofibrate, isopropyl 2-(4-(4-chlorobenzyl)phenoxy)-2-methyl propanoate (Fibrane).

Single step conversion of fenofibrate to fibrane

ACS Spring Meeting 2021

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