We recently developed a photoreactive unit based on a heteroaromatic indolizine scaffold, which enabled efficient release of alcohols and carboxylic acids through photooxidation induced by irradiation of red LED light (660 nm) in the presence of a catalytic amount of a photosensitizer under air.<sup>1</sup> Diverse functional molecules such as anticancer drug and fluorescence dye were released quantitatively within 5 min. The method was also successfully applied for the release of a fluorescence dye from a peptide-indolizine-dye conjugate. Considering the broad scope of alcohols and carboxylic acids applicable for this method and the fast reaction rate cause by the irradiation of biopermeable red light, diverse applications of this method in biology and material research are expected.

Indolizines enabling rapid uncaging of alcohols and carboxylic acids by red light-induced photooxidation

ACS Spring Meeting 2021

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