Viral infection involves a large number of protein-protein interactions (PPIs) between virus and its host. The complex process of metastasis involves the formation of migratory cells, the so called epithelial mesenchymal transition (EMT), which enables cancer cells to break loose from the primary tumor mass and to enter the bloodstream. To break loose from the primary cancer, cancer cells have to down-regulate the cell-to-cell adhesion molecuIes(CAMs) which keep them attached to neighboring cancer cells. Virus–receptor interactions play a key regulatory role in viral host range, tissue tropism, and viral pathogenesis. Common viral receptors include sialylated glycans, cell adhesion molecules such as immunoglobulin superfamily members and integrins and phosphatidylserine receptors, Viruses are nanoscale entities containing a nucleic acid genome encased in a protein shell called a capsid and in some cases are surrounded by a lipid bilayer membrane. These shells are modified in cases in which the capsid assembles around a nucleic acid or on a lipid bilayer. As part of their entry and infection strategy, viruses interact with specific receptor molecules expressed on the surface of target cells. The novel coronavirus SARS-CoV-2 entry into host cells is mediated by its spike glycoprotein (S-glycoprotein), and the angiotensin-converting enzyme 2 (ACE2) has been identified as a cellular receptor. Electrostatic and Van der Waals are compared to hydrogen bonding in proteins (PPI) showing a virus binding to the human receptor protein surface.

Virus host receptor adhesion

ACS Spring Meeting 2021

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.