Currently, we are immersed in a pandemic caused by the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which severely threatens public health worldwide. This is a highly-pathogenic human coronavirus (CoV) first reported in Wuhan, China, where a pneumonia of unknown cause was detected in December 2019. The shortage of really effective drugs or vaccines to treat the serious disease caused by this coronavirus, COVID-19, has prompted scientists to intensify their work. Scientific accumulated knowledge for years has shared in an unprecedented inter- and multi-disciplinary fashion. Drug discovery community has focused the efforts on identify pharmacological targets and therapeutic candidates that finally can provide the desired treatment to combat the pandemia. This communication will present some of the main virus and host-based targets that can guide the efforts of medicinal chemistry to discover new drugs together with a description of the new ones recently discovered. Furthermore, results from our group focused on target and ligand-based drug discovery using chemical libraries will be also described. The joint work of the scientific community, both the private and the public sectors, will undoubtedly help to find a solution to the current serious global health problem.

Therapeutic targets and emerging drugs for COVID-19

ACS Spring Meeting 2021

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.