The fast-dissolving oral drug delivery systems are gaining more interest in the pharmaceutical industry. Recently, electrospinning of nanofibrous webs incorporating drugs was shown to be a very favorable approach for the development of fast-dissolving drug delivery systems. The very large surface area and highly porous structure along with the amorphous state of the drugs make these nanofibrous webs suitable for fast-dissolving oral drug delivery systems since they can readily dissolve or disintegrate upon contact with a liquid medium. Cyclodextrins (CDs) are classified as cyclic oligosaccharides and they are already being used in drug formulations since hydrophobic drug molecules become water-soluble by inclusion complexation with the doughnut-shaped cavity of CD molecules. The electrospinning of polymer-free drug/CD inclusion complex formulations can be yielded into nanofibrous webs with fast-dissolving character and such electrospun nanofibrous webs would be quite proper for designing fast-dissolving oral drug delivery systems for pharmaceutical products. Additionally, the electrospinning of nanofibers from aqueous solutions of CD inclusion complexes with drugs has the advantage where it is possible to use only water for the electrospinning without the need of polymeric carrier and organic solvents. In our study, we have developed orally fast-dissolving drug delivery systems from polymer-free nanofibrous webs of ibuprofen/CD inclusion complexes using the electrospinning technique. Ibuprofen is extensively used in the therapy; however, it is poorly water-soluble and suffers from low bioavailability. On the other hand, its water solubility and so the bioavailability has been enhanced by inclusion complexation with CD. The electrospinning of ibuprofen/CD aqueous solutions has yielded defect-free nanofibers and collected as in the form of self-standing and flexible nanofibrous webs. The electrospun ibuprofen/CD nanofibrous webs have been readily dissolved when placed in water or when wetted with artificial saliva. The results elucidated that electrospun ibuprofen/CD nanofibrous webs could be promising material as a fast-dissolving oral drug delivery system.

Ibuprofen/cyclodextrin inclusion complex nanofibers for fast dissolving oral drug delivery system

ACS Spring Meeting 2021

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