Peganum Nigellastrum Bunze, a Chinese medicinal plant is a rich source of bioactive alkaloids and used for the treatment of rheumatism, inflammation, abscesses, and other maladies.. Also, the basic fraction of Peganum Nigellastrum has been shown to exhibit antitumor activity. Recently isolated indolo-quinazolinones such as Peharmalines, Pegaharmalines, and Nigellastrines have attracted the attention of synthetic chemists owing to their unique structures and bioactivities. We have developed an aza-Nazarov approach towards the same, and progress will be presented.

Studies towards the synthesis of quinazolinone alkaloids-pegaharmalines, peharmalines and nigellastrines

ACS Spring Meeting 2021

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