Malaria has been a major health concern for decades, continually causing human suffering and mortality despite global efforts to control the life-threatening disease.The search for new antimalarial drugs is crucial, but the criteria for new antimalarial drugs are demanding because they need to be safe, efficacious, affordable, and active against resistant malarial strains. Computer modelling studies suggest that fluorophenyl substituted and related N-imidazoylbenzamides have the potential to be effective antimalarial compounds. Progress on the synthesis of this and related compounds is reported. A convergent approach coupling a variety of N-phenyl substituted imidazolyls with various N-alkyl substituted benzamides appeared most logical and is underway.

N-Imidazolyl benzamides for the fight against malaria

ACS Spring Meeting 2021

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