Neonicotinoid insecticides are a one of the most widely using pesticides in current world. Since the 1980s, because of their insect specific neurotoxicity, these chemicals used for the extermination of pests in house and agriculture. The widespread use of neonicotinoids has led to measurable concentrations in broad range of environment, in many agricultural products and processed foods. These issues have raised concern about neonicotinoids in terms of human exposure and potential health risks. Studies of the exposure of humans to neonicotinoids and their metabolites are essential to estimate exposure pathways and potential health risks. However, few biomonitoring of neonicotinoids and their metabolites in human was reported previously, especially in Asia where a one of the most pesticides consumed area in current world.<br/>In this study, we are collecting spot urine samples and questionnaire that asking personal data (physical, habitat, and food habitat) from three prefecture (Niigata, Ishikawa, and Fukuoka) in Japan. Using the concentration data of neonicotinoids and personal data, we estimate the exposure level, situation, and pathway of neonicotinoid in Japan. Additionally, we compare the site difference of neonicotinoids concentration among sampling sites.<br/>In the results, the most frequently detected compound was Acetamiprid-N-desmethyl (N-DMA, 84.4%), metabolite of Acetamiprid, following thiamethoxam (THX, 52.3%). Detected frequencies of neonicotinoids were relatively low, and it is considered that these are caused by short half-life of neonicotinoids in human body. No significant difference among three sampling sites was detected. The result of correlation analysis between detected concentration and personal data, vegetable preference of donor was positively correlated with detected THX and N-DMA concentrations. In conclusion, neonicotinoid pollution is distributed in human society in Japan, and further biomonitoring is required.

Human biomonitoring of neonicotinoid insecticides in Japan

ACS Spring Meeting 2021

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.