The use of radioactive metal ions for both therapeutic and diagnostic applications has led to significant advances in the field of nuclear medicine. A key requisite for their implementation in this area, however, is that they be stably attached to a biological targeting vector with an appropriate bifunctional chelating agent. Given the diverse chemical properties of radiometals that are useful for nuclear medicine, the design and optimization of bifunctional chelating agents is an important aspect for the development of novel radiopharmaceutical agents. In this presentation, we will discuss our efforts to synthesize and understand the coordination chemistry of new chelating agents for nuclear medicine. A particular emphasis is given on structural features that give rise to distinct selectivity patterns for different radiometal ions and how they might be applied in different contexts.

Ligand design strategies for the chelation of theranostic radiometals

ACS Spring Meeting 2021

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