A new class of REDOX responsive glycopolymer based fluorescent nanogel was prepared for stimuli-responsive and target specific delivery of anticancer drug. A functional block copolymer (BCP) poly(pentafluorophenyl acrylate)-b-poly(furfuryl methacrylate) (PPFPA-b-PFMA) of controlled molecular weight was achieved via reversible addition-fragmentation chain transfer (RAFT) polymerization technique . The activated pentafluorophenyl ester functionality was replaced by the amine functionality of glucosamine to introduce the amphiphilic BCP poly[2-(acrylamido) glucopyranose]-b-poly(furfuryl methacrylate) (PAG-b-PFMA). Furthermore, biocompatible gelatin QDs (GQDs) was attached to PAG-b-PFMA to induce fluorescence activity in the glycopolymer. A model anticancer drug, Doxorubicin was loaded in the polymer during the crosslinking process via Diels-Alder reaction using dithio-bismaleimidoethane (DTME), a REDOX responsive crosslinker. The anticancer activity (in-vitro) of the drug loaded micelle was observed over MBA-MD-231, human breast cancer cell line and monitored via confocal fluorescence microscopy and flow cytometric analyses (FACS). The cytotoxicity of the prepared glycopolymer based nanogel over the MBA-MD-231 cell line was assessed via MTT assay and it was observed that the synthesized nanogel was non-cytotoxic in nature.

Fluorescence active glycopolymer nanogel for redox responsive delivery of anticancer drug

ACS Spring Meeting 2021

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.