Aromatic bicyclic [5+5] azoles are important structural motives for medicinal chemistry where members of this class have shown antifungal, antiviral, and even anticancer activity. While the biological activity of imidazo[1,2-a]imidazol-7-ium salts have been widely investigated and many routes exist for their synthesis, few syntheses of the related imidazo[2,1-c][1,2,4]triazol-1-ium salts have been reported and certain substitution patterns have remained elusive. Here we report an alternative synthetic pathway to a variety of substituted 9H-benzo[4,5]imidazo[2,1-c][1,2,4]triazol-1-ium salts which allows their preparation under mild conditions and from readily available starting materials.

Iodine mediated CH activation leading to benzo[4,5]imidazo[2,1-c][1,2,4]triazol-1-ium salts

ACS Spring Meeting 2021

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