Cross-electrophile coupling has come to be synonymous with the coupling of alkyl electrophiles with aryl or acyl electrophiles over the past decade. However, the concept of cross-coupling two electrophiles under reducing conditions has enormous potential because it avoids the need for a nucleophilic coupling partner. Several key questions arise in moving beyond the established chemistry: What new reactions should be explored? How can cross-selectivity be achieved? What advantages do reducing conditions confer? This talk will introduce recent advances from my research group at UW-Madison that demonstrate several new avenues for reductive and cross-electrophile coupling in Csp2-Csp2 bond formation, C–N bond formation, and C-C bond activation.

Opportunities in cross-electrophile coupling beyond Csp2–Csp3 bonds

ACS Spring Meeting 2021

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