Metal-organic frameworks (MOFs) are a class of porous materials composed of inorganic molecular building blocks (MBBs) and organic linkers, and have many applications including gas storage and separation, catalysis, and drug delivery. Drug delivery applications of MOFs are of particular interest as these materials can have a high loading of biologically active molecules in the large cavities of the porous material. Presented here is the encapsulation of four heteroleptic ruthenium(II) bis(2,2’-bipyridine)2(X)2 complexes (X = acetonitrile (ACN), 6,6’-dimethyl-2,2’-bipyridine (DMBpy), pyridine (Py), and 4-aminopyridine (4-aminopy) within the zinc(II)/benzene tricarboxylic acid MOF, USF-2 as a proof of concept for the encapsulation of photoactive guest molecules and photorelease of the attached ligand(s) (X). The photorelease of the attached ligands inside USF-2 was determined optically using steady-state absorption methods. The results indicate photorelease of both RuBpy(ACN)2 and RuBpy(Py)2 while no release is observed DMBpy and 4-aminopy ligands. The lack of release for the RuBpy(DMBpy) and RuBpy(4-aminopy)2@USF-2 may be due to steric restrictions and/or alteration of the ligand photorelease mechanism due to confinement.

Encapsulation and ligand photodissociation of heteroleptic ruthenium (II) bis-(2,2’-bipyridine)(X)2 complexes in the Zn(II)-based metal organic framework, USF-2

ACS Spring Meeting 2021

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