In this study we investigate the assembly of nanofibrillated 2,3-dicarboxyl cellulose (<i>nf</i>-DCC) or simply “CNF” into anisotropic layered membranes for transdermal drug delivery systems utilizing their high internal surface and tunable content of surface charges for drug loading. In particular loading and release of the potent nonsteroidal anti-inflammatory drug (NSAID) piroxicam (PRX) was investigated. PRX has both analgesic and antipyretic activity and is frequently applied for treatment of acute and chronic rheumatoid arthritis or osteoarthritis. However as gastrointestinal disorders may occur upon oral administration, transdermal administration is commonly recommended. PRX exhibits poor solubility in many solvents including water potentially constituting an obstacle for its applications. Adsorptive loading of considerable quantities of the drug onto CNF membranes of high PRX affinity and large specific surface is demonstrated to render respective materials attractive as a transdermal drug delivery patch since it overcomes the above obstacle.

Transdermal NSAID release patches made from anisotropic 2,3-dicarboxycellulose hydrogel membranes

ACS Spring Meeting 2021

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