This presentation will detail the development of the nickel-catalyzed<br/>arylation of oxazoles and benzoxazoles using halide and phenolic electrophiles. The use of microscale high-throughput experimentation for both the rapid identification of optimal reaction parameters and the investigation of the electrophile scope will be discussed. The scope and efficiency of the arylation using several electronically and structurally varied aryl electrophiles will be described.

Nickel-catalyzed arylations of azoles using halide and phenolic electrophiles

ACS Spring Meeting 2021

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