Over the past several decades we have seen major shifts in the way medicinal chemists discover novel medicines. Technology advances have significantly increased our ability to triage compound design and synthesize compounds faster. New approaches in structural biology have enhanced our ability to visualize molecules and their corresponding binding sites. Targets have become increasingly difficult to drug and the term “undruggable” has become a popular catch phrase. Our discovery teams have moved from local to global and our understanding of biology has deepened and extended our reach. This lecture will discuss some of the past trends, current status of the industry and hypothesize where the future of medicinal chemistry and drug discovery is headed.

ACS Earle B. Barnes Award for leadership in chemical research management: Drug discovery - where are we headed

ACS Spring Meeting 2021

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