Although the origins of microwave effects are currently under dispute, microwave irradiation is a well-known method for the rapid heating of reaction mixtures. There are numerous examples, found in the literature, which describe advantages over classical heating methods. Based on this knowledge, we have sought to reap the rewards of microwave irradiation as a suitable vehicle for the rapid activation of disarmed sugar donors, thereby shortening reaction times and increasing reaction efficiency. Furthermore, we realize that one necessity for synthetic glycan assembly is in the development of new protecting groups and as such we are developing these moieties to be “activated” under microwave irradiation conditions. This talk will focus on utilizing the microwave to manipulate functional microwaveable entities and as such manipulate deprotection protocols and also utilize microwave activatable donors to facilitate glycan assembly; all conducted without any external additives.

Manipulating glycans with microwavable activating groups for oligomer assembly

ACS Spring Meeting 2021

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