Organic synthesis is an enabling science with immense impact in many areas of research, including modern medicine and biology. The need for sustainable and green research to reduce the global carbon footprint leads to the emerging importance of “green chemistry”. Among all new technologies, flow chemistry in one of most important in this way. Flow chemistry can be applied to privileged scaffolds with high pharmacological importance. Furthermore, a greener and sustainable protocol for the synthesis of 3,3-disubstituted indolenine through interrupted Fischer indolisation reaction is reported. Indolines and indolenines are embedded in diverse naturally occurring and synthetic biologically relevant molecules. We developed a telescoped approach for reactions that allowed generation of a library of indolenines and indolines with limited solvent consumption and manual intermediate work-up procedures. Having development a reliable and scalable route to indolenines and indolines, we decided to explore the use of this scaffolds as substrates of peptidomimetic frameworks through a multicomponent reaction. The MCRs symbolize a strategy to reach eco-compatibility and eco-sustainability in the modern chemistry. Isocyanide-based MCRs (iMCR) represent the vertebral column of MCR’s chemistry. We synthetized a library of compounds in batch mode to shift in flow approaches exploring the rapid library generation.

Flow chemistry applied to privileged scaffolds

ACS Spring Meeting 2021

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.