Acetaminophen (APAP) is a common analgesic and an active ingredient in many painkillers such as Tylenol and Percocet. APAP misuse can lead to Acetaminophen Induced Liver Injury (AILI), which accounts for a striking proportion of acute liver failures in the United States. A better understanding of the mechanisms of APAP toxicity will provide insight into preventing/ treating APAP overdose. Research in our group is focused on investigating the one-electron oxidation products of the peroxidase catalyzed reaction involving APAP. This work uses horseradish peroxidase (HRP) as a model for cytochrome p450 to catalyze the one-electron oxidation of APAP with hydrogen peroxide. HPLC was utilized to characterize the oxidation products of this reaction. Additional investigations show the role of ascorbate in APAP free radical reactions.

One-electron oxidation of acetaminophen

ACS Spring Meeting 2021

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.