There are a plethora of pharmaceuticals that cite sun sensitivity, a phototoxic effect, as a potential side effect. There are multiple pathways that elicit a phototoxic response in the body; however, the current FDA standards cite only the molar absorptivity and the lambda max as predicting factors, which leads to false positives and negatives. By using absorption and emission spectroscopy, the solvatochromic shift method was used to determine the change in dipole moment upon excitation of sodium naproxen.  By gathering data on the photophysical properties of multiple pharmaceuticals, potential trends could lead to a model being developed that would allow for a more accurate prediction of the sun sensitivity side effect.

Exploring the photophysical properties of sodium naproxen as predictors for the sun sensitivity side effect

ACS Spring Meeting 2021

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.