Esters are a class of compounds which have some of the widest array of real-world applications. They are used for their fragrance in products like perfumes and air fresheners, and for their flavor in food products. Among various esters, the synthesis of allylic esters has been studied widely in the literature due to their role as important scaffolds for bioactive molecules as well as pharmaceuticals. In the past decades, the advancements in the transition metal catalyzed C-H functionalization boosted the area of C-C and C-X (X = C, O, N, P, S) bond formation reactions Particularly the area of oxidative coupling approach for the direct C-H activation have been an area of great interest. It has emerged as one of the most important strategies for the development of new and greener synthetic methodologies in organic synthesis in recent years. In this current study, we would like to report the successful use of nickel metal as catalysts for oxidative esterification of cyclohexene and its derivative with various carboxylic acids. In our attempts to carry out the reaction by reacting benzoic acid with cyclohexene in presence of NiBr2 (10 mol%) and Di-tert-butylperoxide (as oxidant), moderate to good yields of the product was obtained.

Non-precious metal catalyzed oxidative esterification of allylic sp3-carbon

ACS Spring Meeting 2021

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