Indole-containing compounds and chalcones have proven useful as scaffolds for a variety of potent molecules with extensive medicinal applications. A series of substituted indoles and indole-based chalcones have been synthesized and evaluated against selected mammalian cancer cell lines and microorganisms. Substituents were chosen to give a range of electron density both on the aromatic ring and at the alpha-beta unsaturated ketone. Compounds with halogen substituents exhibited the highest potency against JEG-3 choriocarcinoma cells, MCF-7 breast cancer cells, and <i>Escherichia coli</i>.

Antiproliferative structure-activity relationships of 5-substituted indoles and indole-based chalcones

ACS Spring Meeting 2021

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