New drugs are being developed to fight diseases and the delivery can determine the effectiveness in combating the disease or infection. Nanofiber technology is a potential mechanism to enhance drug delivery in the treatment of burn victims. Using biocompatible nanofibers which were made through the process of electrospinning, to make a degradable covering or bandage that releases antibiotics to combat infections associated with burn or accident skin wounds. Polymers such as chitosan, maltose, and sodium alginate are the most promising in producing nanofibers and are easy to electrospin. Collagen is being added as one of the polymers because of its aid in tissue engineering and the success of electrospinning nanofibers. The plan is to infuse manuka honey with some of our nanofibers because of its antimicrobial properties and broad spectrum. The hypothesis is that the various polymers used to make fibers will interact differently with silver sulfadiazine, an antibiotic used in inhibiting the growth of bacteria, and with the manuka honey. The method used to make nanofibers is electrospinning the dissolved solutions of the polymers. The fibers are then spun and collected on a collection sheet. Nanofibers have the potential to be used for wound dressing in the future.

Incorporation of silver-based antibiotics in various polimer-based nanofibers for drug delivery enhancement

ACS Spring Meeting 2021

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.