This research project concerns the development of hydrogels for the development of an intelligent drug delivery system, for direct application in the cancer treatment. In an aqueous medium, the self-assembly of supramolecular complexes allows the formation of a hydrogel, capable of trapping hydrophilic bioactive compounds. The disassembly of the hydrogel allows the release control of bioactive compounds. Some polymer chains are able to fit into the hydrophobic cavities of cyclodextrins to form a supramolecular collar called pseudopolyrotaxane. This supramolecular network can be transformed into polyrotaxane in order to slow down the kinetics of disassembly and to more rigorously control the release of the trapped molecules. This system can then contain various drugs, in particular biguanide derivatives endowed with anti-cancer properties. Their bioavailability can be improved by a more localized and controlled release over time. The interest of this project is therefore to develop a specific release system that is less restrictive for the patient

Development of a therapeutic hydrogel based on cyclodextrin polyrotaxane

ACS Spring Meeting 2021

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.