In this work, gold mediated s- arylation in KRAS(G12C) protein was achieved by using rationally designed Au(III) complexes along with affinity ligand as a new strategy. Au(III) complex specifically modified cysteine (G12C) via c-s arylation. Au(III) complexes also specifically inhibit the KRAS(G12C) mutant cells over other KRAS mutant cells.

Develop gold mediated covalent inhibitor for KRAS(G12C)

ACS Spring Meeting 2021

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.