Kynurenic Acid (KYNA) is a known antagonist to ionotropic glutamate receptors in the brain, which allows for the regulation of basal dopamine (DA). However, in order to deliver KYNA into the brain, large probes have to be employed which can unfortunately result in a great deal of harm. The field of controlled drug release has promise as an answer to this problem. Recent research has shown the ability to controllably release a variety of target compounds such as dexamethasone from a GO/PPy nanosheet film coating. A similar coating of poly(3,4-ethylenedioxythiophene) functionalized carbon nanotubes (PEDOT/CNT) has been shown to increase selectivity and sensitivity for in vivo detection of resting DA through the use of square wave voltammetry (SWV). We are interested in the ability of the PEDOT/CNT coatings to be loaded with KYNA, which can then be controllably released. We successfully optimized the PEDOT/CNT coatings on glassy carbon electrodes (GCE), as shown by a decrease in impedance and increased charge storage capacity. KYNA loading is performed via copolymerization as a new, PEDOT/CNT-KYNA coating is electrochemically synthesized. Following this, the next steps are release of the KYNA via voltage stimulation. Controlled release will be performed using this technique and then measured using high performance liquid chromatography (HPLC).

Electronically controlled delivery of kynurenic acid via PEDOT functionalized carbon nanotube coatings

ACS Spring Meeting 2021

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.