As the synthesis of medicinal chemistry targets and libraries expand beyond amidations and SnAr reactions to more challenging chemo- and biocatalyzed transformations, the need to quickly identify best conditions covering a broad range of sterically & electronically diverse monomers and templates becomes paramount. Herein, we present ongoing efforts to rapidly test multivariate reactions crossing both monomers and templates, detailing successes, failures, and the applicability of this workflow to Big-Data generation.

Enabling medicinal chemistry through high-throughput experimentation

ACS Spring Meeting 2021

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.