Electrochemistry has made major contributions to organic synthesis through its “green” methodology, higher atom economy, and minimal waste. Organic electrosynthesis utilizes electrical current to drive the activation of organic molecules via the removal or addition of electrons. Due to its selective redox of organic molecules, organic electrosynthesis can perform reaction transformations that have not been generated traditionally through the use of conventional chemical reagents. Electrochemistry is a beneficial asset for chemists providing clean transformations, mild reaction conditions, simple scalability, high functional group tolerance, low energy consumption, and a step away from the use of toxic redox reagents. Through this research, we have developed a strategic electrochemical approach to perform a C-H functionalization of a TEMPO-lated benzylic substrate. In the presence of a terminal alkyne substrate, base, and with the use of electricity, we can efficiently achieve a Csp-Csp<sup>3</sup> bond formation between the benzylic and alkyne position. The identification of the optimal conditions and substrate scope tolerability are currently under investigation in the laboratory, with promising preliminary results.

C-H functionalization for Csp-Csp<sup>3</sup> bond formation via electro-organic synthesis

ACS Spring Meeting 2021

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C-H functionalization for Csp-Csp3 bond formation via electro-organic synthesis

C-H functionalization for Csp-Csp³ bond formation via electro-organic synthesis