Microwave technology opens up new opportunities to the synthetic chemist in the form of new reactions that are not possible using conventional heating. The interest in the microwave assisted organic synthesis has been growing during the recent years. The short reaction times provided by microwave synthesis make it ideal for rapid reaction scouting and optimization of reaction conditions, allowing very rapid progress through the hypotheses–experiment–results iterations, resulting in more decision points per unit time.With the easy availability of microwaves its use in chemistry has gained momentum and this has led the microwave heating to emerge as powerful technique to promote a wide variety of chemical reactions. In this research aromatic nitriles, benzonitrile,<i> p</i>-nitrobenzonitirle, <i>p</i>-bromobenzonitrile, 1,4-dicyanao benzene, and other aromatic nitriles were reacted with sodium azide in the presence of a Lewis acid base catalyst using microwave assisted synthesis in a [3+2] cycloaddition reaction to produce substituted Tetrazoles. The products were purified and characterized using IR and NMR. The reaction conditions and procedures for these syntheses will be described in this poster.

[3+2] Cycloaddition reactions of aromatic nitriles with sodium azide to form tetrazoles

ACS Spring Meeting 2021

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