Malassezia furfur is a yeast (Ascomycota) that is part of the normal microbiota of the human body. The microbiota acts as a protective layer for the human body; it is composed of many microorganisms, among these are fungi. However, M. furfur it is an opportunistic microorganism, because it is the causative agent of superficial mycosis. Due to the great advances in nanotechnology, it has been possible to develop methods that have established mechanisms in antimicrobial and antifungal agents. Through this study, we seek to evaluate how the efficiency of a drug becomes affected when interacting with nanoparticles. We will work with AgNPs, AuNPs and ZnONPs. Its antifungal inhibitory abilities will be evaluated separately and also, the synergism between the nanoparticles and the antifungal medication Fluconazole will be observed. Preliminary, ZnONPs with and without Fluconazole have more inhibition, 1.9mm and 2.1mm respectively. Furthermore, AgNPs with and without fluconazole shows a measure of inhibition of 1 mm and 1.2 mm respectively. In relation to the AuNP, in the preliminary data it was not possible to see any reaction. Posteriorly, more test will be done to continue studying the antifungal abilities of the nanoparticles and to determine the percentage of synergism with the drug Fluconazole.

Antifungical effects of silver, gold and zinc oxide nanoparticles in combination with fluconazole against Malassezia furfur

ACS Spring Meeting 2021

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.